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New agent causes leukemia cell death

I found this article about a method for inhibiting leukemia cells. 

A team of researchers at Virginia Commonwealth University Massey Cancer Center has discovered an entirely new mechanism of action for a novel pharmacological agent currently in clinical trials in patients – the kinase inhibitor BAY 43-9006 – which was designed to disrupt the survival pathways of tumor cells….

"We were surprised to find that the killing effects of Bay 43-9006 in human leukemia cells had very little to do with inhibition of the Raf-1 pathway," Grant said. "Instead, the major mechanism of lethality of this compound involved down-regulation of a protein known as Mcl-1, which plays a critical role in protecting leukemic cells from apoptosis.

Source:  Medicalnewstoday.com

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This entry was posted by David Austin on Monday, October 24th, 2005 at 1:20 pm and is filed under Uncategorized . You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

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